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5-HTP CR has a delivery system that releases 5-HTP slowly and steadily over a period of time. 5-HTP is a drug-free amino acid derived from a plant that naturally increases the body’s level of serotonin, the chemical messenger that affects emotions, behavior, appetite, and sleep. Today’s stress-filled lifestyles and dietary practices may negatively affect how the body handles serotonin. Regular use of Unique Verve’s 5-HTP CR helps promote a more positive outlook and greater appetite control.*

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Clinical Application:

  •  Supports Healthy Biosynthesis of Serotonin
  •  Supports Healthy Mood and Positive Outlook
  •  Supports Normal Appetite
  •  Supports Restful Sleep Pattern

Formulated To Exclude:

Wheat, gluten, corn, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners, and artificial preservatives.


Take one tablet, up to two times daily, with a meal. Do not exceed recommended dose.
Consult your healthcare professional prior to use if you have, or suspect you have, a medical condition or are taking prescription drugs for depression, migraines, Parkinson’s disease, or psychiatric disorders. Not for use by children.

All Unique Verve Formulas Meet or Exceed cGMP Quality Standards and are manufactured and stored in the temperature and humidity regulated facility in USA.

cGMP = Current Good Manufacturing Practice certification means that every aspect of all Unique Verve manufacturing process has been examined, including laboratory/testing methods (for stability, potency and product formulation)

Made and Packaged in the USA

Supplement Facts:

Serving Size 1 Tablet
Servings Per Container 60


Calcium (as dicalcium phosphate dihydrate) 27 mg 2%
5-HTP (5-hydroxytryptophan) 100 mg ** (from Griffonia simplicifolia)(seed)

Other Ingredients:

Hydroxypropyl methylcellulose, hydroxypropyl cellulose, ascorbyl palmitate, silica, and coating (tapioca maltodextrin, sunflower lecithin, palm oil, and guar gum).


*Disclaimer: Statements made regarding dietary supplements, or products sold through this website have not been evaluated by the Food and Drug Administration. They are not intended to diagnose, treat, cure, or prevent any disease. You should consult with a healthcare provider before beginning any dietary supplements.

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health concerns.


5-hydroxytryptophan (5-HTP) is a precursor to serotonin. In the body, the essential amino acid tryptophan (when acted upon by the enzyme tryptophan hydroxylase) converts to 5-HTP. The compound is subsequently decarboxylated to serotonin, thereby elevating extracellular serum serotonin levels. Supplementing with 5-HTP bypasses the somewhat limiting conversion of tryptophan to 5-HTP. Oral 5-HTP is well-absorbed in the intestine without the need for a transporter; other amino acids do not compete with it for absorption. It easily crosses the blood-brain barrier, is not degraded by the enzymes that degrade tryptophan, and it is excreted through the kidneys.

Mood and Comfort: Serotonin regulates many normal brain activities, increases norepinephrine and dopamine, and is important in regulating mood and behavior. Adequate levels of serotonin are associated with normal calmness and relaxation.

Several studies have demonstrated that 5-HTP supports a healthy frame of mind, good energy levels, ease of movement, and restful sleep. Published studies (dose~100-600 mg/day) have also demonstrated the effectiveness of 5-HTP supplementation in supporting cerebral comfort.

Appetite: Used in a high dose (i.e., 300 mg/three times a day), 5-HTP decreased food consumption and reduced weight. This result may relate to the effect of 5-HTP in supporting normal hypothalamic regulation, which includes appetite homeostasis. However, nausea at this relatively high dose was a common complaint. In other research, sublingual 5-HTP administered five times per day for eight weeks in adult overweight women significantly supported feelings of post-meal hunger satisfaction.

Hormones and Sleep: 5-HTP is thought to effect the HPA axis, as it has the ability to raise plasma cortisol levels, to cause transient increase in growth hormone (at 150 mg dose), and in men only, to support healthy levels of thyroid stimulating hormone. Serotonin is also converted to melatonin; thus, supplementation has similar effects. Support of sleep quality is likely related to 5-HTP’s ability to increase the length of rapid eye movement (REM). In children, supplementation with 5-HTP may help modulate arousal level and support peaceful sleep.


  1. Fibromyalgia and the serotonin pathway: https://pubmed.ncbi.nlm.nih.gov/9802912/  

  2. Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation: https://pubmed.ncbi.nlm.nih.gov/17176492/  

  3. 5-Hydroxytryptophan: a clinically-effective serotonin precursor: https://pubmed.ncbi.nlm.nih.gov/9727088/
  4. 5-hydroxytryptophan in major depression: a positron emission tomography study on patients and healthy volunteers: https://pubmed.ncbi.nlm.nih.gov/1882697/
  5. L-5-hydroxytryptophan alone and in combination with a peripheral decarboxylase inhibitor in the treatment of depression: https://pubmed.ncbi.nlm.nih.gov/3265988/
  6. Double-blind study of 5-hydroxytryptophan versus placebo in the treatment of primary fibromyalgia syndrome: http://pubmed.ncbi.nlm.nih.gov/2193835/
  7. Primary fibromyalgia syndrome and 5-hydroxy-L-tryptophan: a 90-day open study: https://pubmed.ncbi.nlm.nih.gov/1521674/
  8. L-5-hydroxytryptophan in the prophylaxis of chronic tension-type headache: a double-blind, randomized, placebo controlled study: https://headachejournal.onlinelibrary.wiley.com/doi/abs/10.1046/j.1526-4610.2000.00067.x
  9.  Plasma 5-hydroxytryptamine (5-HT) in migraine during an attack-free period: https://pubmed.ncbi.nlm.nih.gov/16643553/
  10. L-5-hydroxytryptophan can prevent nociceptive disorders in man: https://pubmed.ncbi.nlm.nih.gov/10721054/
  11. Disorder in the serotonergic system due to tryptophan hydroxylation impairment: a cause of hypothalamic syndrome? https://www.karger.com/Article/Abstract/271918
  12. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan: https://pubmed.ncbi.nlm.nih.gov/1384305/
  13. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients: https://pubmed.ncbi.nlm.nih.gov/9705024/
  14. Satiety and amino-acid profile in overweight women after a new treatment using a natural plant extract sublingual spray formulation: https://pubmed.ncbi.nlm.nih.gov/19752879/
  15. Inhibitory effect of ritanserin on the 5-hydroxytryptophan-mediated cortisol, ACTH and prolactin secretion in humans: https://pubmed.ncbi.nlm.nih.gov/1851310/
  16. Transient effect of L-5-hydroxytryptophan on pituitary function in men and women: https://pubmed.ncbi.nlm.nih.gov/6600170/
  17. Effects of 5-hydroxytryptophan on the sleep of normal human subjects: https://www.sciencedirect.com/science/article/abs/pii/0013469471901477
  18. L -5-hydroxytryptophan treatment of sleep terrors in children: https://pubmed.ncbi.nlm.nih.gov/15146330/



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