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CoQ10 Max

$58.00

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CoQ10 Max is Unique Verve’s proprietary, micro-emulsified CoQ10 formula that offers unparalleled absorption and bioavailability. This formulation has been shown in clinical trials to be over eight times more absorbable than powdered CoQ10 and more than twice as bioavailable as oil-based or so-called “nano”-dispersed formulas on the market. The proprietary multilipid carrier employed in CoQ10 Max is unmatched for optimal utilization in the support of cardiovascular and energy-based health needs.

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Description

Key Benefits & Actions:

  • Innovative, Soy-Free, Five-Lipid Blend for Enhanced Absorption
  • Supports Natural Energy Generation and Mitochondrial Function
  • Supports Plasma/Tissue CoQ10 Levels
  • Supports Health/Functioning of the Cardiovascular System
  • Supports Neuromuscular and Central Nervous System Health

Does Not Contain:

Wheat, gluten, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Directions:

Take one softgel one to two times daily, or as directed by your healthcare practitioner. Optimal results may be achieved by consuming with meals that contain fat.

Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner.

All Unique Verve Formulas Meet or Exceed cGMP Quality Standards

cGMP = Current Good Manufacturing Practice certification means that every aspect of all Unique Verve manufacturing process has been examined, including laboratory/testing methods (for stability, potency and product formulation)

Made and Packaged in the USA

Supplement Facts:

Serving Size 1 Softgel
Servings Per Container: 60

Ingredients:

Percent Daily Values (DV) are based on a 2,000 calorie diet.
** Daily Value (DV) not established.
Calories : 15
Total Fat : 1.5 g 2%
CoenzymeQ10(asubiquinone)(KanekaQ10®) : 100mg

Other Ingredients:

Proprietary blend of palmitic acid, oleic acid, and linoleic acid, safflower oil (non-GMO), medium-chain triglycerides, gelatin, vegetable glycerin, and annatto.

Kaneka Q10® is a registered trademark of Kaneka Corp.

LEGAL DISCLAIMER:

*Disclaimer: Statements made, or products sold through this website have not been evaluated by the Food and Drug Administration. They are not intended to diagnose, treat, cure, or prevent any disease.

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health concerns.

Discussion

Coenzyme Q10 (CoQ10) is a fat-soluble substance that plays a major role in energy production and antioxidant protection in the body. It is found in the body primarily in its interchangeable ubiquinone and ubiquinol forms. In general, CoQ10 supports mitochondrial energy production, antioxidant activity, cell membrane stabilization, gene expression and apoptosis, and neurological and cardiovascular health. Levels of CoQ10 in the body can be affected by a number of factors. Dietary contribution of CoQ10 is minimal and serum levels tend to decline with age or can be reduced due to drug-induced nutrient depletion.

Synthesis of CoQ10 in the body is regulated by the enzyme HMGCoAreductase. A variety of factors can inhibit HMG-CoA reductase and hinder CoQ10 production and availability, resulting in a potential increase in oxidative stress and a decrease in energy generation. In the event of reduced production, or drug-induced nutrient depletion, physicians recommend supplementation with CoQ10 to help maintain normal levels in the body. Supplementation with CoQ10 has been found to promote favorable outcomes for a targeted group of patients and to improve quality of life, energy levels, neurological health maintenance, exercise tolerance, and muscle comfort for a wide range of individuals. A research study utilizing functional intracellular assay (FIA) suggested that CoQ10 may be a potential peripheral biomarker of antioxidant status in neurological health maintenance.

Cardiovascular health is particularly dependent upon CoQ10 because of the heart muscle’s exceedingly high energy demand. The value of CoQ10 supplementation on cardiovascular health has been confirmed by ongoing human research studies. A randomized, double-blind, placebo-controlled study utilizing the same bioidentical, naturally yeast-fermented CoQ10 found in CoQ10 Max formulas was conducted in a select group of 49 patients. Researchers observed that supplementation with 100mg/d of CoQ10 successfully restored plasma levels and significantly increased total CoQ10 levels by 127%.

Results from the highly anticipated Q-SYMBIO research study were reported in May 2013. Prior to the Q-SYMBIO study, researchers had observed that myocardial CoQ10 levels were inversely related to heart health and function. The Q-SYMBIO results, infact, supported this association. In the randomized, double-blind, placebo controlled Q-SYMBIO study, 420 patients were assigned to parallel groups to receive either the CoQ10 found in CoQ10 Max (100 mg three times per day) or placebo. Within three months, researchers observed a reduction in N-terminal pro-brain natriureticpeptide (NT-proBNP), an important marker of heart health, in the CoQ10 supplemented patients. After two years, patients who were supplemented with CoQ10 had significant cardiovascular improvement overall compared to placebo.

CoQ10 Max contain a unique, micro-emulsified, and highly bio available form of ubiquinone delivered by a five-lipid–blend carrier system. The two formulas feature US-manufactured KanekaQ10, a pure form of bioidentical CoQ10 fermented from natural yeast, and do not contain the impurities found in synthetically processed CoQ10. The quality and reliability of this non-GMO and self-affirmed GRAS CoQ10 is supported by 30 years of manufacturing, safety, and clinical studies.

REFERENCES

  1. Coenzyme Q10 Depletion in Medical and Neuropsychiatric Disorders: Potential Repercussions and Therapeutic Implications: https://pubmed.ncbi.nlm.nih.gov/23761046/
  2. Linus Pauling Institute: http://lpi.oregonstate.edu/infocenter/othernuts/coq10/
  3. Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomized trial: https://link.springer.com/article/10.2165/00002018-200629080-00007
  4. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke: https://pubmed.ncbi.nlm.nih.gov/15210526/
  5. The clinical use of HMG CoA-reductase inhibitors and the associated depletion of coenzyme Q10. A review of animal and humanpublications: https://pubmed.ncbi.nlm.nih.gov/14695925/
  6. Biochemical functions of coenzyme Q10: https://pubmed.ncbi.nlm.nih.gov/11771674/
  7. Primary and secondary coenzyme Q10 deficiency: the role of therapeutic supplementation: https://pubmed.ncbi.nlm.nih.gov/23452285/
  8. The effect of coenzyme Q10 in statin myopathy: https://www.ahajournals.org/doi/full/10.1161/JAHA.118.009835
  9. Coenzyme Q10 deficiency in patients with Parkinson’s disease: https://pubmed.ncbi.nlm.nih.gov/22542608/
  10. Clinical aspects of coenzyme Q10: an update: https://pubmed.ncbi.nlm.nih.gov/19932599/
  11. Coenzyme Q10 treatment in serious heart failure: https://pubmed.ncbi.nlm.nih.gov/10416042/
  12. Effect of coenzyme Q10 supplementation on heart failure: a meta-analysis: https://pubmed.ncbi.nlm.nih.gov/23221577/
  13. Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin: a randomized double-blind study: https://pubmed.ncbi.nlm.nih.gov/17681347/
  14. Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC397155/
  15. The effect of Coenzyme Q10 on morbidity and mortality in chronic heart failure: https://pubmed.ncbi.nlm.nih.gov/25282031/
  16. Important new data shows CoQ10 improves survival in heart failure patients: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287951/

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