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Omega3 Bio Pure

$59.90

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(1 customer review)

The Omega3 BioPure formula features MaxSimil® monoglyceride fish oil that has a three times greater EPA+DHA absorption rate than an equivalent dose of other leading fish oils. This formula is IFOS five star certified to ensure the world’s highest standards for purity, potency and freshness. This fish oil is non-GMO, certified sustainable from Scandinavia and antibiotic free.

 

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Description

The Omega3 BioPure formula features MaxSimil® monoglyceride fish oil that has a three times greater EPA+DHA absorption rate than an equivalent dose of other leading fish oils. Through the use of MaxSimil patented lipid absorption enhancement technology (PLATform), the fish oil is absorption-ready and can be directly assimilated in the intestinal tract for maximum benefit.
All Unique Verve Formulas Meet or Exceed cGMP Quality Standards

Key Benefits & Actions:

  • Positively Affects the Production of Arachidonic Acid-Derived Eicosanoids
  • Supports Cardiovascular Health
  • Supports Healthy Mental Functioning
  • Supports Healthy Glucose and Insulin Metabolism
  • By Supplying the Precursors EPA and DHA, Helps the Body Generate Specialized Proresolving Lipid Mediators, Such as Resolvins and Protectins

Directions:

Take one softgel daily, or use as directed by your healthcare practitioner.

Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner.

All Unique Verve Formulas Meet or Exceed cGMP Quality Standards cGMP = Current Good Manufacturing Practice certification means that every aspect of all Unique Verve manufacturing process has been examined, including laboratory/testing methods (for stability, potency and product formulation)

Does Not Contain:

Wheat, gluten, corn, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Made and Packaged in the USA

Supplement Facts:

Serving Size: 1 Softgel
Servings Per Container: 60

Ingredients:

† Percent Daily Values (DV) are based on a 2,000 calorie diet.
** %Daily Value (DV) not established.
Calories 10
Total Fat 1 g 1%†
MaxSimil® Fish Oil Concentrate 1.3 g **
Total Omega-3 Fatty Acids 860 mg **
EPA (eicosapentaenoic acid) 600 mg **
DHA (docosahexaenoic acid) 260 mg **

Other Ingredients:

Softgel (fish gelatin, vegetable glycerin, and purified water), GRAS enteric coating (ethylcellulose, sodium alginate, purified water, medium-chain triglycerides, oleic acid, vegetable stearic acid, and ammonium hydroxide), and mixed natural tocopherols.

Contains: Fish (anchovy and/or sardine [sources of fish oil], tilapia and/or pangasius [sources of fish gelatin]).

Manufactured using MaxSimil® fish oil. MaxSimil® is a registered trademark of Ingenutra Inc. Protected under US patents 8,119,690 and 8,198,324; Canadian patents 2672513 and 2677670.

LEGAL DISCLAIMER:

*Disclaimer: Statements made, or products sold through this website have not been evaluated by the Food and Drug Administration. They are not intended to diagnose, treat, cure, or prevent any disease.

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health concerns.

Discussion

MaxSimil® Patented Lipid Absorption Enhancement Technology (PLATform)

The MaxSimilPLATform is a novel monoglyceride delivery system that enhances absorption of lipid-based and lipid-soluble nutraceutical and food ingredients. This technology has been applied to Unique Verve’s Omega3 BioPure formulas in order to create a unique vehicle by which to deliver EPA and DHA. Due to the fact that monoglyceride oils are intrinsically emulsifiers and are, by nature, in a readily absorbable form, they can bypass the body’s normal fat digestion process. These qualities make Omega3 BioPure an excellent method for delivering omega-3 fatty acids, especially to individuals with digestive, pancreatic, or gall bladderchallenges. Studies show that MaxSimil fish oils (FO) have three times (300%) greater absorption of EPA and DHA compared to other leading fish oils.

Quality

Omega3 BioPure formulas are made using proprietary MaxSimil compositions containing monoglyceride FO with no additional ingredients, carriers, or excipients. Each fish-gelatin soft gel is enteric-coated, and every batch of fish oil ensure the world’s highest standards for purity, potency, and freshness. The fish oil is non-GMO, certified sustainable from Scandinavia, and antibiotic-free. Additionally, it is eco-friendly because the greater absorption of EPA and DHA ultimately means that fewer grams of fish oil need to be harvested for the same benefit.

In Vitro and In Vivo Animal Studies

The ability of MaxSimil-enhanced EPA and DHA to positively influence growth inhibition and apoptosis in colorectal, breast, lung, and prostate diseased cell lines was first demonstrated in a series of in vitro studies. Researchers subsequently set out to demonstrate efficacy in animal models after oral administration. In three separate animal models, MaxSimil EPA and DHA forms showed superior activity on diseased cell-line growth inhibition and cytokine production when compared to control, corn oil, krill oil, or the parent forms ethylester (EE) EPA and ethyl ester (EE) DHA. These in vivo animal studies proved that orally supplemented MaxSimil EPA and DHA were well-absorbed and bioactive. Researchers postulated that the observed superior effects of MaxSimil EPA and DHA forms were the result of enhanced absorption, and they set out to prove this hypothesis.

Preclinical Bioavailability Studies

The in vivo pharmacokinetic studies in rodents involved a comparison between MaxSimil DHA FO and its parent EE DHA FO and an analysis of blood concentrations of DHA over time. The doses used were equivalent to human doses of 3 g/day and 30 g/day; the latter was included primarily to investigate toxicity at high doses.

Researchers found that MaxSimil DHA FO had a three times (3x) higher peak concentration, a 3x higher saturation potential at the high dose, and a 3x higher absorption rate (at a 3 g/day equivalent human dose)than its parent DHA FO. No toxicity was observed at either dose level. This research demonstrated superior bio availability and presumably better exposure of cells to DHA.

Clinical Bioavailability Study

A phase 1, double-blind, randomized, crossover, pharmacokinetic study was performed in 20 healthy adults aged between 19 and 71 years who were administered 6 g (containing 1800 mg EPA and 1200 mg DHA) per day of EE FO or MaxSimilFO. Parameters studied were plasma EPA and DHA concentration (as percent of total fatty acids), Cmax, and AUC. Compared to EE EPA+DHA, the results indicated that at peak concentration, MaxSimil EPA and DHA forms were 3x higher, they reached maximum concentration faster, and maintained their plasma levels longer. The finding in the animal study was validated: the MaxSimil FO instantaneous absorption was 3x greater than the EE form. Likewise, the AUC over 24 hours was also more than 3x higher (P<.0001) for MaxSimil EPA and DHA (MaxSimil FO).

Not only did this study confirm the bioavailability findings in the animal study, but it also demonstrated that after 24 hours, the MaxSimil FO maintained 2-3x higher blood levels of EPA and DHA than the EE FO. This means that, given a daily dose, circulating EPA and DHA levels can be expected to ramp up over time and remain high with steadily increasing exposure of cells to EPA, DHA, and their metabolites. Based on the results of the bioavailability studies, an individual would get more EPA and DHA from MaxSimil FO than from EE FO gram for gram. Furthermore, as shown in the animal studies, one could anticipate enhanced effects. It is noteworthy that all 20 adults who completed the study saw their omega-3 absorption enhanced when taking the MaxSimil enhanced FO.

Expanding Research

In vitro and animal studies have demonstrated the positive effects of MaxSimil FO on airway immune response(e.g., IgE, leukocytes); the expression of COX-2, NF-kB, cytokines (e.g., IL-6, IL-8), MUC5AC, and mucin; and Ca(2+) hypersensitivity in lung tissues. In other research, rats subjected to eight weeks of a high-fat, high carbohydrate diet were either not supplemented or provided 3 g/day of MaxSimil DHA. Compared to the data from the non-supplemented group, the data from the MaxSimil DHA supplemented group clearly showed apositive impact on cardiovascular health parameters. Measures included blood pressure, heart rate, serum lipid levels, cytokine production, aortic wall thickness, and a DHA:AA ratio in aortic tissue, which correlated with the production of resolv in D2 and D3 metabolites.

A Note About Resolvins and Other EPA and DHA Metabolites

Specialized proresolving lipid mediators, such as resolvins, protectins, and maresins, are EPA and DHA metabolites naturally produced in vivo through enzymatic conversion of EPA and DHA. These mediators aid the body’s “clean-up” response to the arachidonic acid cascade. Rather than supplying a single molecule ormetabolite, which would mirror the pharmaceutical model, Omega3 BioPure fish oils provide all the benefits of EPA and DHA as well as the expected and desirable benefits of their metabolites.

REFERENCES

  1. Anti-proliferative effects of a new docosapentaenoic acid monoacylglyceride in colorectal carcinoma cells: https://pubmed.ncbi.nlm.nih.gov/23932824/
  2. Polyunsaturated fatty acid monoglycerides, derivatives, and uses thereof: https://patents.google.com/patent/US8119690
  3. Eicosapentaenoic acid and docosapentaenoic acid monoglycerides are more potent than docosahexaenoic acid monoglyceride toresolve inflammation in a rheumatoid arthritis model: https://pubmed.ncbi.nlm.nih.gov/26022389/
  4. Docosahexaenoic acid derivative prevents inflammation and hyperreactivity in lung: implication of PKC-Potentiated inhibitoryprotein for heterotrimeric myosin light chain phosphatase of 17 kD in asthma: https://pubmed.ncbi.nlm.nih.gov/21057106/
  5. Pro-resolving action of MAG-DHA in lung inflammatory models related to cystic fibrosis: https://pubmed.ncbi.nlm.nih.gov/25781052/
  6. New omega-3 derivatives reduce airway inflammation and prevent rho-kinase activation in an allergic model of asthma: https://www.longdom.org/abstract/new-omega3-derivatives-reduce-airway-inflammation-and-prevent-rhokinase-activation-in-an-allergic-model-of-asthma-6120.html
  7. Effect of docosahexaenoic acid monoacylglyceride on systemic hypertension and cardiovascular dysfunction: https://pubmed.ncbi.nlm.nih.gov/25910811/
  8. Omega-3 fatty acids and their lipid mediators: towards an understanding of resolvin and protectin format:https://pubmed.ncbi.nlm.nih.gov/22326554/
  9. Primary prevention of cardiovascular disease with a Mediterranean diet: https://www.nejm.org/doi/full/10.1056/nejmoa1200303
  10. Mediterranean diet reduces cardiovascular events in people with heart disease, study shows: https://pubmed.ncbi.nlm.nih.gov/27114468/
  11. Latest evidence of the effects of the Mediterranean diet in prevention of cardiovascular disease: https://www.researchgate.net/publication/264797391_Latest_Evidence_of_the_Effects_of_the_Mediterranean_Diet_in_Prevention_of_Cardiovascular_Disease
  12. Anti-inflammatory effect of virgin olive oil in stable coronary disease patients: a randomized, crossover, controlled trial: https://pubmed.ncbi.nlm.nih.gov/17375118/

 

1 review for Omega3 Bio Pure

  1. Stephanie (verified owner)

    Optimal Omega-6:Omega-3 ratio is 1:1. Natalie recommended I get mine tested and I was shocked that it was 39:1. I retested after 10 months of taking this supplement 2-3 times per day and my ratio is now 3:1. My back pain that I’ve had since my fusion in 2007 has greatly improved since supplementing with Unique Verve Omega3 BioPure formula. Although I still deal with chronic pain, the severity and frequency has decreased. This is primarily because my mid/low back pain is caused by inflammation from strenuous activity (even just standing around for a long time or a very active day). So why this specific supplement? I recommend reading Natalie’s post on why you can trust her supplements as opposed to just buying some from amazon. If you google recommended Omega-3 brands, they fail compared to this one whether it be little amount of EPA/DHA or stored improperly resulting in rancid fish oil (that actually damages your health rather than improving it).

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