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Probiotic Integrum

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Probiotic Integrum is a vegetarian, dairy- and gluten-free, four-strain probiotic totaling 30 billion CFU† per capsule. Each vegetarian capsule is sealed in nitrogen-purged aluminum blister packs to serve as protection from factors proven to compromise the stability of probiotics such as heat, moisture, and oxygen.

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Description

Probiotic Integrum provides four researched strains of beneficial bacteria, including the extensively studied HN019® strain of Bifidobacterium lactis.

These live microorganisms have proven health benefits and well-established safety, and have been tested for epithelial cell adhesion and/or resistance to low pH.*

To further support resistance to low pH and the delivery of microorganisms to the small intestines, Unique Verve employs DRcapsTM gastro-resistant capsules. These specially designed, innovative capsules help slow exposure of actives to stomach acid and ensure more targeted release.

All Unique Verve Formulas Meet or Exceed cGMP Quality Standards and are manufactured and stored in the temperature and humidity regulated facility in USA.

Key Benefits & Actions:

  • Helps Maintain a Healthy Intestinal Microecology
  • Supports the Natural Immune Response
  • Supports Bowel Regularity
  • Supports Lactose Digestion

Does Not Contain:

Wheat, gluten, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Directions:

Take one capsule once or twice daily, or as directed by your healthcare practitioner.

Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner.

All Unique Verve Formulas Meet or Exceed cGMP Quality Standards and are manufactured and stored in the temperature and humidity regulated facility in USA.

cGMP = Current Good Manufacturing Practice certification means that every aspect of all Unique Verve manufacturing process has been examined, including laboratory/testing methods (for stability, potency and product formulation)

Made and Packaged in the USA

Supplement Facts:

Serving Size: 1 capsule
Servings Per Container: 30

Ingredients:

** %Daily Value (DV) not established.
Proprietary Blend 409 mg (50 Billion CFU†) **
Lactobacillus acidophilus La-14®
Bifidobacterium longum Bl-05TM
Lactobacillus plantarum Lp-115®
HOWARU® Bifido 167 mg (50 Billion CFU†) **
(Bifidobacterium lactis HN019®)

Other Ingredients:

HPMC (acid-resistant capsule), microcrystalline cellulose, magnesium stearate, and silica.

†Colony-Forming Unit
HOWARU® and the HOWARU® logo are registered trademarks of DuPont or its affiliates.
HN019® is a registered trademark of FonterraTM Limited and is licensed to DuPont Nutrition Biosciences.

LEGAL DISCLAIMER:

*Disclaimer: Statements made, or products sold through this website have not been evaluated by the Food and Drug Administration. They are not intended to diagnose, treat, cure, or prevent any disease.You should consult with a healthcare provider before beginning any dietary supplements.

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health concerns.You should consult with a healthcare provider before beginning any dietary supplements.

Discussion

Supplementation with probiotics has many mechanisms of action that benefit health, including but not limited to: (1) supporting metabolic activity, such as the production of short-chain fatty acids and vitamins, nutrient absorption, and digestion of lactose; (2) adhering to intestinal epithelial cells to help maintain a healthy balance of organisms in the intestinal tract; (3) helping to establish populations of good bacteria after disruption in balance; (4) supporting immune function; (5) promoting intestinal epithelial cell survival; (6) supporting healthy bowel function; and (7) degrading oxalates.

Common challenges associated with probiotic supplementation are maintaining stability of the organisms during distribution and shelf life and, once taken by a consumer, survival of the organisms as they travel through the digestive tract so that they reach the target tissue (intestines) alive. To help ensure stability, Unique Verve packages the Probiotic Integrum capsules in sealed, nitrogen-purged aluminum blister packs to serve as protection from factors proven to compromise the stability of probiotics, such as heat, moisture, and oxygen. Careful selection of organisms is another way Unique Verve helps ensure stability.

Careful organism selection, as performed for Probiotic Integrum, is also a critical aspect of supporting digestive survival. To further support resistance to low pH and the delivery of microorganisms to the small intestines, Unique Verveemploys DRcaps™ gastro-resistant capsules. These specially designed, innovative capsules help slow exposure of activesto stomach acid to promote a more targeted release.

HOWARU™ (Bifidobacterium lactis HN019®)

Discovered in 1899, B lactis play a key role in the human microflora throughout a person’s life. Researchers have identified strain HN019® as having excellent probiotic potential based upon its ability to survive the transit through the human gastrointestinal tract, adhere to epithelial cells, and proliferate. B lactis HN019® has been extensively studied, and its safety and effectiveness is well accepted. To assess the impact of Bifidobacterium lactis HN019® supplementation on whole-gut transit time in adults, 100 subjects were given daily doses for 14 days of 17.2billion colony-forming units (CFU), 1.8 billion CFU, or placebo. Decreases in mean whole-gut transit time over the 14-daystudy period were statistically significant in the high-dose group and the low-dose group, but not in the placebo group. This level of dosing also supported other parameters of healthy GI function, as were self-reported by patient survey. In another study of preschool-age children, supplementing milk for one year with 1.9 x 10 CFU per day B lactis HN019® and2.4 g/day of prebiotic oligosaccharides supported both healthy iron status and weight gain. In a randomized, double-blind, placebo-controlled human dietary intervention study in elderly subjects (>60 yrs.), supplementary B lactis HN019® resulted in statistically significant increases in the beneficial organisms bifido bacteria and lactobacilli.

Lactobacillus acidophilus (Lactobacillus acidophilus La-14)

This common inhabitant of the human mouth, intestinal tract, and vagina, is also found in some traditional fermented milks (e.g., kefir) and is widely used in probiotic foods and supplements. It has a history of safe human consumption. The L acidophilus La-14 strain is of human origin and has been identified as a type A1 L acidophilus. L acidophilus shows excellent adhesion to human epithelial cell-lines.

Lactobacillus plantarum (Lactobacillus plantarum Lp-115)

This bacteria was isolated from plant material and is abundantly present in lactic acid-fermented foods, such as olives and sauerkraut. In vitro studies have shown that Lplantarum strain Lp-115 has excellent adhesion to epithelial cell lines. In addition, L plantarum is resistant to low pH conditions and survives the presence of bile at duodenal concentrations.

Bifidobacterium longum (Bifidobacterium longum Bl-05)

The B longum Bl-05 strain is well accepted as safe for human consumption. B longum is resistant to low pH and bile salts and is well suited to the intestinal environment.

REFERENCES

  1. Mechanisms of probiotic action: Implications for therapeutic applications in inflammatory bowel diseases: https://academic.oup.com/ibdjournal/article/14/11/1585/4654966
  2. Oxalate-degrading bacteria of the human gut as probiotics in the management of kidney stone disease: https://pubmed.ncbi.nlm.nih.gov/20602988/
  3. Beneficial effects of lactic acid bacteria on human beings: https://www.tandfonline.com/doi/abs/10.3109/1040841X.2010.536522
  4. Oxalate consumption by lactobacilli: evaluation of oxalyl-CoA decarboxylase and formyl-CoA transferase activity in Lactobacillus acidophilus: https://pubmed.ncbi.nlm.nih.gov/17953571/
  5. Dietary Bifidobacterium lactis (HN019) enhances resistance to oral Salmonella typhimurium infection in mice: https://pubmed.ncbi.nlm.nih.gov/10832963/
  6. Effects of the consumption of Bifidobacterium lactis HN019 (DR10TM) and galacto-oligosaccharides on the microflora of the gastrointestinal tract in human subjects: https://www.sciencedirect.com/science/article/abs/pii/S0271531703001349
  7. Dose-response effect of Bifidobacterium lactis HN019 on whole gut transit time and functional gastrointestinal symptoms in adults: https://pubmed.ncbi.nlm.nih.gov/21663486
  8. Effects of Bifidobacterium lactis HN019 and prebiotic oligosaccharide added to milk on iron status, anemia, and growth among children 1 to 4years old: https://pubmed.ncbi.nlm.nih.gov/20601905/
  9. Impact of consumption of different levels of Bifidobacterium lactis HN019 on the intestinal microflora of elderly human subjects: https://pubmed.ncbi.nlm.nih.gov/17315077/
  10. Factors involved in adherence of lactobacilli to human Caco-2 cells: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC202009/
  11. Adherence of Lactobacillus species to human fetal intestinal cells: https://pubmed.ncbi.nlm.nih.gov/7153393/
  12. Role of commercial probiotic strains against human pathogen adhesion to intestinal mucus: https://pubmed.ncbi.nlm.nih.gov/17897389/
  13. Acid, bile, and heat tolerance of free and microencapsulated probiotic bacteria: https://pubmed.ncbi.nlm.nih.gov/18034741/

Reviews

  1. Stephanie

    This probiotic is truly a wonder. I got my gut bacteria/flora tested after months of taking this probiotic. I had healthy optimal levels of each specific bacterial strain listed in this supplement. I attribute a lot of my gut health improvement to this probiotic. On a more surprising note, it is the only thing that helps me restore my vaginal flora when things are off. I was battling chronic BV symptoms for at least a year or two. Natalie recommended I break open this capsule, mix with high quality organic coconut oil, and use the mixture similar to a vaginal suppository. After a week of that, my symptoms were gone.

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    Nutritional, supplemental, fitness, and wellness information provided by the Functional Medicine Skincare Therapist, Natalie Maibenko, Unique Verve Inc is designed for educational purposes only. If the Client has any concerns or questions about her/his health, the Client should always consult with a physician or other healthcare professional. Do not disregard, avoid, or delay obtaining medical or health-related advice from the healthcare professional.

    Any claims made with respect to dietary supplements, including those made with respect to supplements available at Unique Verve, have not been evaluated by the Food and Drug Administration, and is not necessarily based on scientific evidence from any source. Dietary supplements are not intended to treat, diagnose, cure or prevent medical conditions or disease. You should consult with a healthcare provider before beginning any dietary supplement program.

    The Client understands that any therapies that the client undertakes at Unique Verve, Inc are undertaken of the client’s own free will. The Client accept that the ultimate responsibility for her/his health care is her/his own and that Functional Medicine Skincare Therapist, Natalie Maibenko, Unique Verve Inc is here to support the client in this. The client hereby agrees to assume full responsibility for any manner of loss, injury, claim or damage whatsoever, known or unknown, incurred as a result of same and the Client, her/his heirs, executors, administrators or assigns for any loss, injury, claim or damage sustained as a result of the Client’s attendance and/or participation.

    The Client have read the above release and waiver of liability, and fully understands its contents and voluntarily agrees to the terms and conditions stated.

    SKIN WELLNESS AND/OR DETOX PROGRAM:

    1. I hereby request and consent to the performance of all aspects of the Detox and/or Skin Wellness program provided by Unique Verve, Inc, Functional Medicine and Skincare Practitioner Natalie Maibenko.
    1. I am consenting to submit to participate in the Detox and/or Skin Wellness program of my own free will, that I will accept any and all responsibility for any undesirable consequences that may occur. I understands that it is my sole responsibility to consult with my physician prior implementing the Detox and/or Skin Wellness program.
    2. I understands that method of the Detox and/or Skin Wellness program involves taking nutritional supplements, recommendation for lifestyle and nutritional changes.
    3. I understand that the Detox program is a private outpatient program that is non-refundable.
    4. I certify that I am here on this and on any subsequent visit or contact, whether by mail, telephone, or in person solely on my own behalf and not as an agent or representative of any federal, state, county, or local government or private agency on a mission of entrapment or investigation.
    5. I understand that due to the nature of the Detox and/or Skin Wellness program, it might involve cleansing reactions in the form of fatigue, headache, or other symptoms. These symptoms will abate with time. Because all individuals are unique, Unique Verve, Inc and a Functional Medicine Skincare Therapist, Natalie Maibenko can not gauge or guess client’s reaction(s) to the Detox and/or Skin Wellness program.
    6. DISCLAIMER and CONDITIONS: Functional Medicine and Skincare Therapist, Natalie Maibenko encourages the Client to continue to visit and to be treated by his/her healthcare professionals, including, without limitation, a physician. The client understands that Natalie Maibenko is not acting in the capacity of a doctor, licensed dietitian-nutritionist, therapist, psychologist or other licensed or registered professional. Accordingly, the client understands that the Functional Medicine and Skincare Therapist Natalie Maibenko is not providing health care, medical or nutrition therapy services and will not diagnose, treat or cure any disease, condition or other physical or mental ailment of the human body. Rather, Functional Medicine and Skincare  Therapist Natalie Maibenko serves as a coach, mentor and guide who helps a client to reach her/his own health and wellness goals through implementing incremental, positive, healthy, sustainable lifestyle changes that help the client to live and thrive using simple methods. The Client has chosen to work with the Functional Medicine and Skincare Therapist Natalie Maibenko and understands that the information received should not be seen as a medical or nursing advice and is not meant to take the place of the client seeing licensed health professionals. Nutritional, fitness, and wellness information provided by Functional Medicine and Skincare Therapist Natalie Maibenko, Unique Verve Inc is designed for educational purposes only. This information is not a substitute for, nor does it replace professional medical advice, diagnosis or treatment. If you have any concerns or questions about your health, you should always consult with a physician or other healthcare professional. Do not disregard, avoid, or delay obtaining medical or health-related advice from your healthcare professional.
    1. PERSONAL RESPONSIBILITY AND RELEASE OF HEALTH CARE RELATED CLAIMS

    The Client acknowledges that the Client takes full responsibility for the Client’s life and well-being, as well as the lives and well-being of the Client’s family and children (where applicable), and all decisions made during and after this program. The Client expressly assumes the risks of the Program, whether or not such risks were created or exacerbated by the provider. The Client releases the Functional Medicine and Skincare Therapist Natalie Maibenko, his/her heirs, executors, administrators and assigns, its officers, directors, shareholders, employees, teachers, lecturers, agents, health counselors and staff (collectively, the Releases) from any and all liability, damages, causes of action, allegations, suits, sums of money, claims and demands whatsoever, in law, admiralty or equity, which against the Releases, the Client ever had, now has or will have in the future against the Releases, arising from the Client’s past or future participation in, or otherwise with respect to, the Program. Unique Verve, Inc and the Functional Medicine and Skincare Therapist, Natalie Maibenko is in no way liable for client’s health or safety.

    1. The Functional Medicine and Skincare Therapist, Natalie Maibenko, is not a licensed Dietitian, Naturopathic Doctor or Medical Physician or Doctor and does not diagnose diseases, disorders or conditions.
    2. Nutritional, fitness, and wellness information provided by the Functional Medicine and Skincare Therapist Natalie Maibenko, Unique Verve Inc is designed for educational purposes only. This information is not a substitute for, nor does it replace professional medical advice, diagnosis or treatment. If you have any concerns or questions about your health, you should always consult with a physician or other healthcare professional. Do not disregard, avoid, or delay obtaining medical or health-related advice from your healthcare professional.
    3. Any claims made with respect to dietary supplements, including those made with respect to supplements available at Unique Verve Inc by the Functional Medicine and Skincare Therapist Natalie Maibenko, have not been evaluated by the Food and Drug Administration, and is not necessarily based on scientific evidence from any source. Dietary supplements are not intended to treat, diagnose, cure or prevent medical conditions or disease. The client should consult with a healthcare provider before beginning any dietary supplement program.
    4. In providing wellness program to the client, the Functional Medicine and Skincare Therapist, Natalie Maibenko, is relying upon the truth, accuracy and completeness of all information the client have provided to her. Any recommendations the client follows for changes in diet, including the use of nutritional supplements, are entirely client’s responsibility.
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      The role of the program is to support and assist the client in reaching the goals, but the success depends primarily on the client’s own effort, motivation, dedication, desire commitment and follow-through.
      The Functional Medicine and Skincare Therapist, Natalie Maibenko does not guarantee that the client will attain a particular result, and the client understands that results differ by each individual. As with any health-related program or service, the results may vary, and will be based on many variables, including but not limited to, client’s individual capacity, life experience, unique health and genetic profile, starting point, expertise and level of commitment.
    6. The client understand that any therapies that she/he undertakes at Unique Verve, Inc are undertaken of her/his own free will.

    The client accepts that the ultimate responsibility for her/his health care is the client’s own and that the Functional Medicine and Skincare Therapist Natalie Maibenko, Unique Verve Inc is here to support the client in this.

    The client hereby agrees to assume full responsibility for any manner of loss, injury, claim or damage whatsoever, known or unknown, incurred as a result of same and the client, her/his heirs, executors, administrators or assigns for any loss, injury, claim or damage sustained as a result of the client’s attendance and/or participation.
    The client has read the above release and waiver of liability, and fully understands its contents and voluntarily agrees to the terms and conditions stated.

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