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B-Complex

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B-Complex contains the entire spectrum of B vitamins to support adrenal and neurological functions. It features activated forms of vitamins B2, B6, and B12; benfotiamine, a fat soluble, more physiologically active form of thiamine; and folate as Quatrefolic®, which is proven to have greater stability, solubility, and bioavailability over calcium salt forms of 5-MTHF.

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Description

All Unique Verve Formulas Meet or Exceed cGMP Quality Standards and are manufactured and stored in the temperature and humidity regulated facility in USA.

Key Benefits & Actions:

  • Positively Affects the Production of Arachidonic Acid-Derived Eicosanoids
  • Supports Cardiovascular Health
  • Supports Healthy Mental Functioning
  • Supports Healthy Glucose and Insulin Metabolism
  • By Supplying the Precursors EPA and DHA, Helps the Body Generate Specialized Proresolving Lipid Mediators, Such as Resolvins and Protectins

Does Not Contain:

Wheat, gluten, yeast, soy protein, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Directions:

Take one capsule once or twice daily, or as directed by your healthcare practitioner.

Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner.

All Unique Verve Formulas Meet or Exceed cGMP Quality Standards and are manufactured and stored in the temperature and humidity regulated facility in USA.

cGMP = Current Good Manufacturing Practice certification means that every aspect of all Unique Verve manufacturing process has been examined, including laboratory/testing methods (for stability, potency and product formulation)

Made and Packaged in the USA

Made and Packaged in the USA

Supplement Facts:

Serving Size: 1 Capsule
Servings Per Container: 90

Ingredients:

** Daily Value not established.
Thiamine (as thiamine HCI) 20mg 1667%
Riboflavin (as riboflavin 5’-phosphate sodium) 20 mg 1538%
Niacin (130 mg as niacinamide and 10 mg as niacin) 140 mg 875%
Vitamin B6 (as pyridoxal 5’-phosphate)
20 mg 1176%
Folate (as Quatrefolic® (6S)-5-methyltetrahydrofolic acid, glucosamine salt) 400 mcg DFE 100%
Vitamin B12 (as MecobalActiveTM methylcobalamin) 400 mcg 16,667% Biotin 400 mcg 1333%
Pantothenic Acid (as d-calcium pantothenate) 150 mg 3000%
Choline (as choline dihydrogen citrate) 30 mg 5%
Benfotiamine 20 mg **

Other Ingredients:

HPMC (capsule), stearic acid, magnesium stearate, and silica.

LEGAL DISCLAIMER:

*Disclaimer: Statements made, or products sold through this website have not been evaluated by the Food and Drug Administration. They are not intended to diagnose, treat, cure, or prevent any disease.

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health concerns.

Discussion

The water-soluble B vitamins have to be absorbed in the small intestine and then go to the liver where they are bio transformed into their active coenzyme forms. B-Complex contains vitamins B1 (thiamine), B2 (riboflavin),B6 (pyridoxine), and B12 (methylcobalamin) in their physiologically-active form making them easier to absorband “ready-for-use.” For example, in patients receiving pyridoxine HCl, only 33 percent responded with an increase in plasma pyridoxal-5’-phosphate (P5P); however, the level increased in all of the patients receivingP5P.

Folate is provided as 5-methyltetrahydrofolate (5-MTHF), which bypasses metabolic steps to folate bioactivity. Despite research showing that folic acid and 5-MTHF have equivalent bioavailability and that supplementation with large doses of folic acid can “force” its conversion to the more active form, 5-MTHF may be the preferred form to replenish folate. This may be especially applicable to those with digestive challenges or genetic variations in folate metabolism. In this formula, 5-MTHF is provided as Quatrefolic—the glucosamine salt of 5-MTHF.In vitro and in vivo studies have proven that Quatrefolic has greater stability, solubility, and bioavailability overcalcium salt forms of 5-MTHF. Folate is stored in small amounts in red blood cells (RBC), and RBC folate has been shown to be higher after supplementation with 5-MTHF compared to folic acid and placebo. Likewise, patients given 5 mg of 5-MTHF experienced plasma levels of 5-MTHF 700% greater than patients given folic acid.

Another unique ingredient in this formula is benfotiamine (S-benzoylthiamine O-monophosphate), a safe, fatsolubleanalog of thiamine. One study showed that it not only raised blood and tissue levels of thiamine at leastfive times higher than the water-soluble salt, but it also remained bioavailable after oral administration up to 3.6times longer than thiamine salt. Benfotiamine is the most potent of a class of thiamine-derived compounds present in small quantities in members of the Allium genus. The superiority of its biological activity compared to thiamine rests in its structure—a thiazole ring opens to allow easy diffusion through a membrane and then closes to become structurally active.

Benfotiamine increases transketolase activity, thereby diverting from three natural, yet destructive metabolicpathways: 1) it decreases the glucose metabolites that lead to the buildup of certain types of detrimental advanced glycation end products (AGEs); 2) it normalizes protein kinase C activity; 3) it protects the retina by preventing the activation of NF-kappaB therein. Research suggests it may also protect the kidneys andendothelial cells. Benfotiamine is useful for replenishing thiamine, this may be especially true in individuals that use the vitamin at a higher rate or in those with lifestyle habits that deplete it.

REFERENCES

  1. Vitamin B6 deficiency in chronic liver disease – evidence for increased degradation of pyridoxal-5-phosphate: https://pubmed.ncbi.nlm.nih.gov/838399/
  2. Serum vitamin B(12) and folate status in patients with inflammatory bowel diseases: https://pubmed.ncbi.nlm.nih.gov/20603044/
  3. Folate deficiency, methionine metabolism, and alcoholic liver disease: https://pubmed.ncbi.nlm.nih.gov/12163145/
  4. Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation inthe methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1914961/
  5. Pharmacokinetic study on the utilisation of 5-methyltetrahydrofolate and folic acid in patients withcoronary artery disease: https://pubmed.ncbi.nlm.nih.gov/14769778/
  6. Pharmacokinetics of thiamine derivatives especially of benfotiamine: https://www.unboundmedicine.com/medline/citation/8929745/Pharmacokinetics_of_thiamine_derivatives_especially_of_benfotiamine_
  7. The potential role of thiamine (vitamin B1) in diabetic complications: https://pubmed.ncbi.nlm.nih.gov/18220605/
  8. Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes: https://pubmed.ncbi.nlm.nih.gov/16936154/
  9. Benfotiamine in treatment of alcoholic polyneuropathy: an 8-week randomized controlled study: https://pubmed.ncbi.nlm.nih.gov/9872352/
  10. Benfotiamine in alcohol damage is a must: https://pubmed.ncbi.nlm.nih.gov/11367995/
  11. New approaches for the treatment of genomic damage in end-stage renal disease: https://pubmed.ncbi.nlm.nih.gov/18089459/

Reviews

  1. Stephanie

    Before taking this B-Complex, I was taking a different B Vitamin of a generic brand from Amazon. I had taken it on and off the past year, but never felt a difference in my energy. If I had to recommend only one of Natalie’s supplements, this would be it. I forgot that Natalie said to start with half a capsule for the first week or so in order to acclimate. I started with a full capsule instead and I felt the difference from Day 1. My energy levels were much higher and consistent throughout the day. I also did not feel the fatigue/sluggish/brain fog that I normally felt. Definitely take this before 2pm in order to avoid restlessness around bedtime.

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