D-Limonene

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D-Limonene is a naturally occurring terpene cold-pressed from orange peel (Citrus sinensis) with FDA GRAS (Generally Recognized As Safe) status — the highest safety rating available. It supports healthy gastric function and GI motility without suppressing or buffering stomach acid production — preserving the healthy acid levels essential for digestion and nutrient absorption.* D-Limonene also supports phase I and II liver detoxification enzyme activity, healthy bile flow, and healthy fat metabolism.* Vegan. Non-GMO. Free of gluten, soy, and dairy.

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D-Limonene Key Benefits & Actions:

  • Supports healthy gastric function and comfortable GI motility without suppressing stomach acid production*
  • Supports healthy peristalsis and gastroesophageal sphincter tone*
  • Supports phase I and II liver detoxification enzyme activity for healthy elimination of metabolic waste products*
  • Supports healthy bile flow and gallbladder function*
  • Supports healthy fat metabolism through its influence on gut microbiota composition*
  • Supports a healthy gut microbiome environment*
  • FDA GRAS (Generally Recognized As Safe) rated — the highest safety classification available*
  • Extracted from Citrus sinensis (orange peel) — naturally derived, vegan, non-GMO*

 

D-Limonene is the primary monoterpene in citrus peel — the compound responsible for the characteristic scent of orange, lemon, and grapefruit oils. Extracted from the peel of Citrus sinensis (orange), it carries the FDA’s GRAS (Generally Recognized As Safe) designation, the highest safety rating available for a food or dietary ingredient.

What distinguishes D-Limonene from many conventional GI support compounds is its mechanism: rather than suppressing or buffering stomach acid production, it works through different pathways to support healthy gastric function. Healthy stomach acid levels are essential for proper digestion — they activate pepsin (the primary protein-digesting enzyme), support the absorption of key minerals including calcium, magnesium, and iron, and provide a critical barrier against ingested pathogens. Approaches that preserve healthy stomach acid while supporting GI comfort are therefore preferable from a functional medicine perspective.*

GI Motility and Gastric Comfort D-Limonene supports healthy peristalsis — the coordinated muscular contractions that move food through the digestive tract — and healthy gastroesophageal sphincter tone, which is the valve between the esophagus and stomach. Supporting healthy sphincter function and normal gastric emptying promotes comfortable upper GI function.* Its gastric acid neutralizing properties are also thought to contribute to a comfortable gastric environment through the coating action of the oil on gastric mucosa.

Liver Detoxification Support D-Limonene aids the liver’s phase I and phase II detoxification enzymes in their role of processing and preparing metabolic waste products, environmental compounds, and fat-soluble substances for elimination. As a lipophilic compound, D-Limonene has an affinity for fat-soluble barriers and supports the lymphatic system’s role in metabolic waste clearance.* This detoxification-supporting activity makes D-Limonene a valuable addition to comprehensive liver support protocols alongside Liver Guard and S-Acetyl Glutathione.

Bile Flow and Fat Metabolism D-Limonene supports healthy bile flow from the liver and gallbladder — bile being the primary vehicle through which fat-soluble metabolic waste products are excreted from the body, and the emulsifying agent essential for healthy fat digestion and absorption. Research suggests D-Limonene also positively influences gut microbiota composition at the phylum and genus level, with correlations observed in healthy fat metabolism outcomes.*

Gut Microbiome Support Research indicates D-Limonene influences the composition and abundance of gut microbiota, supporting a healthy microbial environment in the GI tract.*

 

D-Limonene Does Not Contain

Wheat, gluten, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Vegan

How To Use D-Limonene

Dosage Instructions: Take 1-2 soft gels of D-Limonene as needed or as recommended by your healthcare practitioner.

Quality, Purity, Potency Guaranteed

All Unique Verve Formulas Meet or Exceed cGMP Quality Standards and are manufactured and stored in the temperature and humidity regulated facility in USA.

cGMP = Current Good Manufacturing Practice certification means that every aspect of all Unique Verve manufacturing process has been examined, including laboratory/testing methods (for stability, potency and product formulation)

Purity and Potency Guaranteed! We use the highest quality raw materials available. Testing is done at various stages of production.

Made and Packaged in the USA

D-Limonene Supplement Facts & Ingredients

Serving Size: 2 softgels
Servings Per Container: 30

D-Limonene Oil (from Citrus sinensis) (Organge Peel Extract)

Other Ingredients

Gelatin, Glycerin, Purified Water, Annatto Extract.

Legal disclaimer

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner.

REFERENCES

  1. D-Limonene: safety and clinical applications: https://pubmed.ncbi.nlm.nih.gov/18072821/#:~:text=Being%20a%20solvent%20of%20cholesterol,and%20gastroesophageal%20reflux%20(GERD).

  2. Modulation of Gut Microbiota by Essential Oils and Inorganic Nanoparticles: Impact in Nutrition and Health: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305160/#:~:text=Dahu%20et%20al.%2C%20demonstrated%20that,improved%20fat%20metabolism%20(38).

  3. Medical Uses for D-Limonene: https://www.bellchem.com/news/medical-uses-for-d-limonene#:~:text=D%2Dlimonene%20aids%20the%20liver’s,mucus%20buildup%2C%20and%20joint%20stiffness.

  4. Antifungal activity and mechanism of d-limonene against foodborne opportunistic pathogen Candida tropicalis: https://www.sciencedirect.com/science/article/pii/S0023643822000792#:~:text=d%2Dlimonene%20can%20inhibit%20the%20foodborne%20opportunistic%20pathogen%20Candida%20tropicalis.&text=d%2Dlimonene%20breaks%20the%20potential,and%20integrity%20of%20cell%20membrane.&text=d%2Dlimonene%20disrupts%20the%20anabolism%20and%20catabolism%20in%20cells.&text=d%2Dlimonene%20has%20a%20promising%20potential%20application%20in%20food%20preservation.

  5. Antifungal Effect and Inhibition of the Virulence Mechanism of D-Limonene against Candida parapsilosis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788451/

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  • our formulas DO NOT CONTAIN: wheat, gluten, soy, animal or dairy products, fish (unless it’s an Omega 3 supplement), shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organism (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.
  • manufactured in USA in a GMP compliant facility
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