Tri-Peptide Complex Avance Elixir

Environ Tri-Peptide Complex Avance Elixir – What Makes It Different

A serum built around the most evidence-supported peptide systems in skincare

The Tri-Peptide Complex Avance Elixir is Environ’s most comprehensive standalone peptide serum — a multi-mechanism formula that addresses collagen synthesis, collagen protection, structural protein quality, and skin tone evenness simultaneously. Understanding why each peptide component was selected requires briefly understanding how the extracellular matrix (ECM) deteriorates with age.

The ECM — the structural scaffold of the dermis — is primarily composed of collagen (I, III, and IV), elastin, fibronectin, and glycosaminoglycans including hyaluronic acid. With age and UV exposure, two processes accelerate its degradation: fibroblasts produce less structural protein, and matrix metalloproteinases (MMPs) — enzymes activated by UV and inflammatory stress — break down existing collagen at an increasing rate. The Avance Elixir’s peptide system targets both sides of this equation.

The peptide complex

Palmitoyl Tripeptide-38 (Matrixyl Synthe’6®): The most advanced of the Matrixyl peptide series, Tripeptide-38 is a messenger peptide that signals fibroblasts to synthesize six structural proteins simultaneously: collagen I, III, and IV; fibronectin; hyaluronic acid; and laminin-5. This makes it a genuinely comprehensive structural regenerator rather than a collagen-only stimulator. Clinical studies have shown measurable reductions in wrinkle volume and depth after regular use.

Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 (Matrixyl 3000®): The original, well-researched Matrixyl complex. Tripeptide-1 mimics a collagen breakdown fragment that signals fibroblasts to produce more collagen (a feedback signalling mechanism the skin uses naturally). Tetrapeptide-7 inhibits the IL-6 signalling pathway that activates MMPs — effectively reducing the rate at which collagen is broken down. Together these produce a dual effect: more collagen synthesized and less collagen degraded.

Tripeptide-10 Citrulline: A peptide with specific activity on fibrillin — the protein component of elastic microfibrils that maintain the elasticity and resilience of skin’s structural network. As fibrillin degrades, skin loses its ability to snap back after expression and movement, contributing to the persistent laxity and loss of definition seen in mature skin. Tripeptide-10 Citrulline addresses this fibrillin dimension that collagen-targeted peptides alone cannot reach.

Tripeptide-1 (Copper Tripeptide GHK-Cu precursor): Supports wound healing, fibroblast activation, and anti-inflammatory activity.

Reproage™ (Astragalus, Atractylodes, and Bupleurum Root Extracts): The same adaptogenic botanical complex used in the 3DSynerge Filler Creme, supporting the skin’s youthful gene expression pathways and stress-resistance mechanisms.

Pseudoalteromonas Ferment Extract: A marine-derived fermentation extract with excellent moisturizing properties that also has documented ability to protect dermal collagen from environmental degradation.

Hydrolyzed Wheat Protein and Hydrolyzed Soy Protein: Plant-derived proteins that form a temporary surface film on the skin, providing an immediate lifting and firming visual effect while the deeper peptide work progresses over time.

Who it’s for

The Avance Elixir is for anyone at any stage of the AVST Step-Up System who wants to add a comprehensive collagen and structural peptide layer to their routine. It is particularly impactful for those in their 40s and beyond managing the visible effects of collagen loss, skin laxity, and uneven tone — and for those whose skin has been exposed to significant environmental stress, UV accumulation, or the hormonal shifts of perimenopause and menopause that accelerate structural ageing. It works especially effectively when used before cosmetic needling, which temporarily opens channels in the stratum corneum and dramatically increases the depth of active ingredient delivery.

If you’re navigating accelerated skin ageing alongside hormonal changes, our VIP Functional Medicine Program combines root-cause clinical investigation with a structured topical protocol — addressing the internal drivers that topicals alone cannot reach.

How to use

After cleansing and toning (and cosmetic needling for advanced users), apply the Avance Elixir and massage gently into the face and neck before your AVST vitamin A moisturiser. Use morning and/or evening. The Elixir may be used alongside the Avance Moisturiser, or independently of it, depending on your skin’s needs and your practitioner’s recommendations.

Ingredients

Aqua (Water), Glycerin, Butylene Glycol, Xanthan Gum, Astragalus Membranaceus Root Extract, Atractyloides Macrocephala Root Extract, Bupleurum Falcatum Root Extract, Polysorbate 20, Palmitoyl Tetrapeptide-7, Pseudoalteromonas Ferment Extract, Hydrolyzed Wheat Protein, Hydrolyzed Soy Protein, Tripeptide-10 Citrulline, Palmitoyl Tripeptide-1, Lecithin, Hydroxypropyl Cyclodextrin, Palmitoyl Tripeptide-38, Sodium Lactate, Carbomer, Tripeptide-1, Caprylyl Glycol, Phenoxyethanol, Disodium EDTA, Triethanolamine.

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