Bio-Pro 50

Bio-Pro 50 – What Makes It Different

• Delivers 50mg of micronized USP-grade bioidentical progesterone per pump for precise, consistent dosing*
• Transdermal delivery bypasses first-pass liver metabolism associated with oral progesterone forms*
• MSM (methylsulfonylmethane) supports cell membrane permeability and enhances transdermal absorption*
• Aloe vera gel provides a soothing, hydrating delivery matrix that promotes penetration of active ingredients*
• Coconut oil and shea butter nourish and protect the skin barrier at the application site*
• Natural preservative system — rosemary, star anise, and radish extract — free of parabens and synthetic preservatives*
• Supports healthy hormonal balance and mood stability during the luteal phase and perimenopause*
• Supports healthy sleep quality associated with progesterone and allopregnanolone activity
• Bio-Pro 50 is formulated for women seeking clean, bioidentical hormonal balance support through a topical delivery route — one with distinct pharmacokinetic advantages over oral progesterone supplementation and a carefully chosen base designed to maximize transdermal absorption.

Why Transdermal Delivery

Oral progesterone undergoes extensive first-pass hepatic metabolism — a significant portion is converted to metabolites including allopregnanolone and other neurosteroids before entering systemic circulation, altering its hormonal effect profile. Transdermal delivery allows progesterone to enter the bloodstream through the dermal capillary network, bypassing the digestive tract and initial liver processing. This allows progesterone to enter circulation in a form closer to the body’s own secretory pattern, supporting more physiologically consistent hormonal balance.*

Each pump of Bio-Pro 50 delivers a precise 50mg dose of micronized USP-grade progesterone derived from wild yam. Micronization reduces particle size to improve skin penetration and absorption consistency across the application site.

The Transdermal Base The base formulation in Bio-Pro 50 is as functional as the active ingredient:

MSM (Methylsulfonylmethane) — included specifically for its ability to increase cell membrane flexibility and permeability, which directly enhances the transdermal delivery of active compounds. MSM’s sulfur-containing structure supports membrane fluidity, facilitating the passage of lipophilic compounds like progesterone through successive skin layers.*

Aloe Vera Gel — serves as the primary delivery matrix. Aloe’s polysaccharide content supports skin hydration and creates a vehicle that promotes the absorption of active ingredients into the dermal layers.*

Coconut Oil (Caprylic/Capric Triglyceride) — provides medium-chain fatty acids that nourish the skin and support the structural integrity of the stratum corneum — the outermost skin layer through which transdermal compounds must pass.*

Shea Butter — rich in fatty acids and vitamins A and E, shea butter nourishes the skin at the application site, maintaining skin health and comfort with consistent daily use.*

Olive Oil and Vitamin E — contribute additional skin-nourishing lipids and antioxidant protection to the application site.*

Natural Preservative System — Bio-Pro 50 is preserved with a proprietary blend of rosemary, star anise, cinnamon essential oils, and radish extract — a natural preservation approach free of parabens, synthetic fragrances, and common irritants frequently found in hormone creams on the market.

Important Usage Notes

Bio-Pro 50 should be used under the guidance of a qualified healthcare practitioner who has reviewed your hormone testing. Application site rotation, dosing frequency, and cycle timing are individualized. Pre-menopausal and perimenopausal women: do not use during the 2 days prior to the expected period through 5 days after its completion, or as directed by your practitioner.

How To Use Bio-Pro 50

Apply Bio-Pro 50 once or twice a day.  Massage into inner arms, thighs, chest or apply to inner forearm and rub arms together or use as directed by your healthcare practitioner. Bio-Pro 50 container yields approximately 70 pumps with 50mg of bio-identical progesterone USP (5%) per pump.

Bio-Pro 50 is all natural product that is intended for external cosmetic use only.

Pre-menopausal/perimenopausal women: Do not use 2 days prior to the expected period through 5 days after completion of the period. Consult your physician for more information.

Warning

For external cosmetic use only.  Discontinue use if irritation or red skin develops and consult a physician. If pregnant, nursing, or if you have a serious medication condition consult a healthcare professional before using.  Do not use with any other progesterone or progestins.  Do not use if tamper evident seal is broken or missing.   Keep out of reach of children. Store in a cool dry place

For external cosmetic use only. Not for internal use.

Quality, Purity, Potency Guaranteed

All Unique Verve Formulas Meet or Exceed cGMP Quality Standards and are manufactured and stored in the temperature and humidity regulated facility in USA.

Manufactured in a US FDA inspected facility.

cGMP = Current Good Manufacturing Practice certification means that every aspect of all Unique Verve manufacturing process has been examined, including laboratory/testing methods (for stability, potency and product formulation)

Purity and potency guaranteed! We use the highest quality raw materials available. Testing is done at various stages of production.

Bio-Pro 50 Supplement Facts & Ingredients

Serving Size: 50mg per pump

Servings Per Container: 70 pumps

Size: 3oz (85 g)

Purified water, micronized progesterone USP (wild yam), glycerin (plant source-kosher), aloe vera gel, caprylic/capric triglyceride, stearic acid, MSM (methyl sulfonyl methane), olive oil, coconut oil, isopropyl palmitate, stearyl alcohol, vitamin E, A proprietary blend of essential oils and herbs (rosemary, star anise, cinnamon) (natural preservative), wild crafted acacia gum, radish extract (natural preservative), carbomer, allantoin, shea butter, sunflower lecithin,
sodium bicarbonate.

Natural Progesterone

Legal disclaimer

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before beginning any dietary supplements.