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5-HTP Plus chewable supplement with Glycine and activated B6 by Unique Verve
5-HTP Plus supplement facts label

5-HTP PLUS

(1 customer review)

$45.00 — or subscribe to save 5%

5-HTP Plus is a practitioner-formulated chewable tablet delivering 5-HTP, glycine, and pyridoxal-5-phosphate (P5P) — three nutrients selected to support the serotonin biosynthesis pathway.* The chewable format allows faster, more direct absorption than standard capsules, making it particularly useful for individuals with GI absorption challenges. Non-GMO. Free of gluten, soy, dairy, and artificial sweeteners.

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5-HTP Plus Benefits:

  • Supports healthy serotonin pathway function through direct 5-HTP precursor supply*
  •  Supports a positive mood and healthy emotional outlook throughout the day*
  •  Supports healthy appetite regulation and satiety signaling*
  • Supports restful sleep onset and sleep quality, particularly at bedtime*
  • P5P (activated B6) is an essential cofactor for 5-HTP-to-serotonin conversion*
  • Chewable/sublingual format allows absorption independent of GI digestive capacity*

In the body, tryptophan converts to 5-HTP via the enzyme tryptophan hydroxylase — often the metabolic bottleneck, as tryptophan competes with other large neutral amino acids for transport across the blood-brain barrier, and tryptophan hydroxylase activity can be suppressed by chronic stress and cortisol. 5-HTP sidesteps this bottleneck entirely: it crosses the blood-brain barrier without competition, is not degraded by enzymes that limit tryptophan, and is efficiently converted to serotonin within neurons.

This formula includes two critical cofactors that distinguish it from standard 5-HTP supplements:

Glycine — a calming, inhibitory amino acid that complements serotonin’s regulatory role and supports sleep onset and neuromuscular relaxation.*

Pyridoxal-5-Phosphate (P5P) — the active coenzyme form of vitamin B6, required by the enzyme aromatic L-amino acid decarboxylase (AADC) to convert 5-HTP into serotonin. Without adequate P5P, this conversion is incomplete regardless of how much 5-HTP is present. Many 5-HTP supplements omit this cofactor entirely.

The chewable tablet format allows partial sublingual absorption — compounds begin entering the bloodstream through oral mucous membranes, bypassing first-pass intestinal processing. This is particularly valuable for individuals with compromised gastric acid production or those needing faster onset.

Serotonin regulates appetite through hypothalamic signaling, influences gut motility (approximately 90% of the body’s serotonin is produced and active in the gut), converts to melatonin in the pineal gland governing circadian rhythms and sleep architecture, and modulates pain perception. Supporting the serotonin pathway nutritionally touches all of these systems simultaneously.*

Precautions: Consult your healthcare practitioner before use if you take SSRIs, MAO inhibitors, triptans, or other serotonin-affecting medications. Not for use by children.

Formulated To Exclude:

Wheat, gluten, corn, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners, and artificial preservatives.

5-HTP Plus Directions:

Suck on, chew, or swallow 1 tablet of 5-HTP 1-3 times a day optimally at bedtime or as recommended by your practitioner.

Consult your healthcare professional prior to use if you have, or suspect you have, a medical condition or are taking prescription drugs for depression, migraines, Parkinson’s disease, or psychiatric disorders. Not for use by children.

QUALITY, PURITY, POTENCY GUARANTEED:

All Unique Verve Formulas Meet or Exceed cGMP Quality Standards and are manufactured and stored in the temperature and humidity regulated facility in USA.

Manufactured in a US FDA inspected facility.

cGMP = Current Good Manufacturing Practice certification means that every aspect of all Unique Verve manufacturing process has been examined, including laboratory/testing methods (for stability, potency and product formulation)

Purity and potency guaranteed! We use the highest quality raw materials available. Testing is done at various stages of production.

Supplement Facts:

Serving Size: 1 Chewable Vegetarian Tablet
Servings Per Container: 90 Chewable Tablets

5-HTP Plus Ingredients:

5HTP (5-hydroxytryptophane), Glycine, Vitamin B6, Pyridoxyl 5 Phosphate (P5P)

Other Ingredients:

Natural Proprietary Sweetener Blend (Dextrose, Stevia) Natural Flavors (Cherry, Peppermint), Vegetarian Magnesium Stearate.

Legal disclaimer:

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. You should consult with a healthcare provider before beginning any dietary supplements.

REFERENCES

  1. Fibromyalgia and the serotonin pathway: https://pubmed.ncbi.nlm.nih.gov/9802912/  

  2. Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation: https://pubmed.ncbi.nlm.nih.gov/17176492/  

  3. 5-Hydroxytryptophan: a clinically-effective serotonin precursor: https://pubmed.ncbi.nlm.nih.gov/9727088/
  4. 5-hydroxytryptophan in major depression: a positron emission tomography study on patients and healthy volunteers: https://pubmed.ncbi.nlm.nih.gov/1882697/
  5. L-5-hydroxytryptophan alone and in combination with a peripheral decarboxylase inhibitor in the treatment of depression: https://pubmed.ncbi.nlm.nih.gov/3265988/
  6. Double-blind study of 5-hydroxytryptophan versus placebo in the treatment of primary fibromyalgia syndrome: http://pubmed.ncbi.nlm.nih.gov/2193835/
  7. Primary fibromyalgia syndrome and 5-hydroxy-L-tryptophan: a 90-day open study: https://pubmed.ncbi.nlm.nih.gov/1521674/
  8. L-5-hydroxytryptophan in the prophylaxis of chronic tension-type headache: a double-blind, randomized, placebo controlled study: https://headachejournal.onlinelibrary.wiley.com/doi/abs/10.1046/j.1526-4610.2000.00067.x
  9.  Plasma 5-hydroxytryptamine (5-HT) in migraine during an attack-free period: https://pubmed.ncbi.nlm.nih.gov/16643553/
  10. L-5-hydroxytryptophan can prevent nociceptive disorders in man: https://pubmed.ncbi.nlm.nih.gov/10721054/
  11. Disorder in the serotonergic system due to tryptophan hydroxylation impairment: a cause of hypothalamic syndrome? https://www.karger.com/Article/Abstract/271918
  12. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan: https://pubmed.ncbi.nlm.nih.gov/1384305/
  13. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients: https://pubmed.ncbi.nlm.nih.gov/9705024/
  14. Satiety and amino-acid profile in overweight women after a new treatment using a natural plant extract sublingual spray formulation: https://pubmed.ncbi.nlm.nih.gov/19752879/
  15. Inhibitory effect of ritanserin on the 5-hydroxytryptophan-mediated cortisol, ACTH and prolactin secretion in humans: https://pubmed.ncbi.nlm.nih.gov/1851310/
  16. Transient effect of L-5-hydroxytryptophan on pituitary function in men and women: https://pubmed.ncbi.nlm.nih.gov/6600170/
  17. Effects of 5-hydroxytryptophan on the sleep of normal human subjects: https://www.sciencedirect.com/science/article/abs/pii/0013469471901477
  18. L -5-hydroxytryptophan treatment of sleep terrors in children: https://pubmed.ncbi.nlm.nih.gov/15146330/

 

Why Buy From Us

  • PHARMACEUTICAL GRADE
  • we offer highest quality supplements that are based on scientifically researched ingredients that are bioavailable and bioactive
  • our formulas are made and packaged to order in USA, thus you’re getting always the freshest product
  • manufactured in the temperature and humidity regulated facility
  • we store our supplements in the temperature and humidity regulated facility, thus maintaining potency and freshness of active ingredients. Unlike many supplements on the market that are not. Amazon for instance came out with the statement saying they can’t control counterfeits in the supplements, let alone storage conditions.
  • our formulas are free of fillers and binders
  • our formulas DO NOT CONTAIN: wheat, gluten, soy, animal or dairy products, fish (unless it’s an Omega 3 supplement), shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organism (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.
  • manufactured in USA in a GMP compliant facility
  • ingredients tested for purity, quality, potency, and composition
  • best manufacturers from all over the USA

HOW TO DETERMINE THE QUALITY OF SUPPLEMENTS?

An important part of any supplement plan is choosing high-quality products. This guarantees that the vitamins, minerals, herbs, botanicals and other nutrients you take will provide the benefits your body needs. To be considered a supplement must be tested by an outside (third-party) source that can verify its quality.

NUTRITIONAL SUPPLEMENTS ARE DIVIDED INTO FOUR CATEGORIES:

  • Pharmaceutical Grade – supplements of this grade meet the highest regulatory requirements for purity, dissolution and absorption as verified by an outside party. These supplements must be 99% pure, with no binders, fillers, dyes, or other unknown substances. These are the supplements that are most often sold by licensed healthcare practitioners. Unique Verve Supplements are Pharmaceutical Grade!
  • Medical Grade – these supplements are of a high grade although they may not conform to the standards of pharmaceutical grade supplements.
  • Cosmetic or nutritional grade – these supplements are most often sold in the health food stores and are not tested for purity, dissolution or absorption. They may not have a high concentration of listed active ingredients.
  • Feed or agricultural grade – these supplements are used for the veterinary purposes. Never use supplements of this grade.

1 review for 5-HTP PLUS

  1. MARTHA MILLER (verified owner) –

Only logged in customers who have purchased this product may leave a review.

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